Pathomorphological and Immuno histochemical Findings of Different Types of Cutaneous Papillomas in Bovines

Bovine Papillomatosis (BP) is a cutaneous viral disease of cattle caused by Bovine Papilloma Virus (BPV).Out of 57 tumor samples, 12 were diagnosed as papillomas or warts (21.05%) of which ten were collected from cattle and two from buffaloes. The animals had either generalized or solitary cutaneous growths in different parts of the body. Grossly, the growths were solitary or multiple, pinkish to greyish-white in colour, 0.5 to 10 cm in diameter, sessile or pedunculated and hard in consistency. Histopathologically, squamous papilloma, viral papilloma (papillomatosis), fibropapilloma and angiokeratoticacanthomatous papilloma were noticed. Immuno histo chemically, PCNA expression in papilloma was observed predominantly in the cells of basal and parabasal layers of epidermis. The PCNA antibodies were very useful marker to detection of cellular proliferation in the bovine cutaneous papillomas.